DESK REVIEWS | 06.02.03. Please outline the total Years lived with disability (YLDs) due to dementia and the source of these estimates

DESK REVIEW | 06.02.03. Please outline the total Years lived with disability (YLDs) due to dementia and the source of these estimates

We could not find specific data for YLD due to dementia. However, a subnational analysis of the Global Burden of Disease project carried out for Brazil between 1990 and 2016 (GBD 2016, 2018) described an increase in the age-standardised YLD rate of 4.9% (2.3% to 7.7%) for Alzheimer’s disease over the years analysed.

References:

GBD 2016. (2018). Burden of disease in Brazil, 1990-2016: A systematic subnational analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 392. http://dx.doi.org/10.1016/S0140-6736(18)31221-2

The years lost due to disability (YLDs) accounted for 99% of the disability-adjusted life years (DALYs) lost due to dementia for people aged 60 and over in 2006. Male experienced 82,212 YLDs and female experienced 202,114 YLDs (Yu et al., 2012).

References:

Yu, R., Chau, P. H., McGhee, S. M., Cheung, W. L., Chan, K. C., Cheung, S. H., & Woo, J. (2012). Trends in prevalence and mortality of dementia in elderly Hong Kong population: projections, disease burden, and implications for long-term care. International Journal of Alzheimer’s Disease, 2012. https://doi.org/10.1155/2012/406852

The GBD estimates (2019) that the YLD’s due to dementia were 35.7 per 100,000 (IHME, 2019).

References:

Institute for Health Metrics and Evaluation (IHME). (2019).  GBD Compare. Seattle, WA: IHME, University of Washington, Available from http://vizhub.healthdata.org/gbd-compare.

According to the Global Health Data Exchange, the YLD of Alzheimer’s disease and other dementias in Indonesia in 2017 is 139,446.64 (Global Health Data Exchange, 2019).

References:

Global Health Data Exchange. (2019). GBD Results Tool. http://ghdx.healthdata.org/gbd-results-tool

This data is not currently available for Jamaica. However, it is notable that in the wider region, according to Parra et al. (2018), in some Latin American countries, dementia leads to a 200% increase in the number of years lived with disability among older persons.

References:

Parra, M.A., Baez, S., Allegri, R., Nitrini, R., Lopera, F., Slachevsky, A., Custodio, N., Lira, D., Piguet, O., Kumfor, F. and Huepe (2018). Dementia in Latin America: Assessing the present and envisioning the future. Available from: https://pure.strath.ac.uk/ws/portalfiles/portal/85132233/Parra_etal_BMCN_2018_Dementia_in_Latin_America_assessing_the_present_and_envisioning.pdf

Disability adjusted life years (DALYs) attributed to dementia was 42,739 in 2016, showing an increase of 9.6% (95% UI –0·4 to 26.2) in age-standardised rates from 1990 to 2016 (Nichols et al., 2019).

References:

Nichols, E., Szoeke, C. E. I., Vollset, S. E., Abbasi, N., Abd-Allah, F., Abdela, J., … Murray, C. J. L. (2019). Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 18(1), 88–106. http://doi.org/10.1016/S1474-4422(18)30403-4

 

Of the 10 leading causes of DALYs in Mexico’s older population, seven conditions are age-related, namely diabetes mellitus, ischemic heart disease, chronic kidney disease, and other organ diseases, Alzheimer’s disease and other dementias, cerebrovascular diseases, and chronic obstructive pulmonary disease. Alzheimer’s and other dementias represent the fifth main cause of DALYS (disability-adjusted life-years) in Mexican older persons (Parra-Rodríguez et al., 2019). However, no accurate data is available on the total deaths due to dementia.

References:

Parra-Rodríguez, L., González-Meljem, J. M., Gómez-Dantés, H., Gutiérrez-Robledo, L. M., López-Ortega, M., García-Peña, C., & Medina-Campos, R. H. (2019). The Burden of Disease in Mexican Older Adults: Premature Mortality Challenging a  Limited-Resource Health System. Journal of Aging and Health, 898264319836514. https://doi.org/10.1177/0898264319836514

Table 40 outlines the deaths, Years lived with disability (YLD), Years of lives lost (YLL), and Disability Adjusted Life Years (DALYs) level 4 caused by Alzheimer’s disease and other dementias in 2019 according to the Global Burden of Disease study (Institute for Health Metrics and Evaluation, n.d.). Dementia was the third most common cause of death with over 2,000 deaths attributable to dementia, almost twice as many as in 2000 (where dementia ranked 6th with 1,144 deaths).

Table 40: Deaths, Years lived with disability (YLD), and Disability Adjusted Life Years (DALYs) caused by dementia in 2017 (Institute for Health Metrics and Evaluation, n.d.).

Deaths YLD YLL DALY
Number 2,066 8,805 20,000 28,806
Rate (per 105) 46 196 445 641
Rank 2019 2 21 7 11
Rank 2000 6 26 12 20

 

References:

Institute for Health Metrics and Evaluation. (n.d.). Global Burden of Disease (GBD). IHME website. Available from: http://www.healthdata.org/gbd.

According to the Global Burden Disease Study (2017), the South Africa’s years lived with disability due to Alzheimer’s disease and related dementias for 2016 were estimated at 24175.92 person-years (0.39%) (Global Burden Disease Study, 2017b).

References:

Global Burden Disease Study. (2017b). Global Burden Disease study: Results Tool (YLDs).