DESK REVIEWS | 06.02.02. Please outline the total deaths and Years of Life Lost (YLL) due to dementia and the source of these estimates

DESK REVIEW | 06.02.02. Please outline the total deaths and Years of Life Lost (YLL) due to dementia and the source of these estimates

According to a study published in 2019 that systematically analysed data from the Global Burden of Disease Study 2016, there were 80,600 deaths (69,174 to 94,940; 95% confidence interval) due to dementia in Brazil in 2016 (GBD 2016, 2019). We could not find specific data for YLL. However, a subnational analysis of the Global Burden of Disease carried out for Brazil (from 1990 to 2016) described a small and non-significant increase in the age-standardised YLL rate of 2.7% (-1.3% to 7.0%) for Alzheimer’s disease over the observed period (GBD 2016, 2018).

References:

GBD 2016. (2018). Burden of disease in Brazil, 1990-2016: A systematic subnational analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 392. http://dx.doi.org/10.1016/S0140-6736(18)31221-2

GBD 2016. (2019). Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 18, 88–106. http://dx.doi.org/10.1016/S1474-4422(18)30403-4

As of July 2018, dementia was the 8th and 5th leading cause of death for males and females, respectively (Healthy HK, 2018, July 19). In 2017, a total of 1,455 people (557 males, 898 females) lost their life due to dementia, which accounted for 3.1% of the total deaths (Centre for Health Protection, 2019). Between 2001 and 2009, people aged 60 and above who died due to dementia, were doubled from 1% to 2% of all deaths. The age-standardised mortality rate (per 100,000 population) of dementia increased from 23.3 to 47.3 for males, and from 45.6 to 62.0 for females. The mortality rates increased exponentially with age (Yu et al., 2012). Between 2001 and 2010, there were 145 deaths of centenarian due to dementia (Yu et al., 2017).

The disability-adjusted life years (DALYs) lost due to dementia for people aged 60 and above was 286,313 in 2006, which included 83,051 (29%) for males and 203,262 (71%) for females. Most of the burden was due to disability, with 284,326 (99%) of years lost due to disability (YLDs) and 1,987 (1%) of years of life lost (YLLs) (Yu et al., 2012).

References:

Centre for Health Protection. (2019, January 11). Number of Deaths by Leading Causes of Death by Sex by Age in 2017. Retrieved from https://www.chp.gov.hk/en/statistics/data/10/27/340.html

Healthy HK. (2018, July 19). Leading cause of all deaths.

Yu, R., Chau, P. H., McGhee, S. M., Cheung, W. L., Chan, K. C., Cheung, S. H., & Woo, J. (2012). Trends in prevalence and mortality of dementia in elderly Hong Kong population: projections, disease burden, and implications for long-term care. International Journal of Alzheimer’s Disease, 2012. https://doi.org/10.1155/2012/406852

Yu, R., Tam, W., & Woo, J. (2017). Trend of centenarian deaths in Hong Kong between 2001 and 2010. Geriatrics & gerontology international, 17(6), 931-936. https://doi.org/10.1111/ggi.12812

As per the Global Burden of Disease (GBD) study (India State-Level Disease Burden Initiative Neurological Disorders Collaborators, 2021), an estimated 129,000 deaths were attributed to Alzheimer’s disease and other dementias in 2019. GBD estimates (2019) indicate there were 117.14 Years of Life Lost (YLL’s) per 100,000 due to dementia (IHME, 2019).

References:

India State-Level Disease Burden Initiative Neurological Disorders Collaborators (2021). The burden of neurological disorders across the states of India: The Global Burden of Disease Study 1990-2019. The Lancet. Global health, 9(8), e1129–e1144.

Institute for Health Metrics and Evaluation (IHME) (2019).  GBD Compare. Seattle, WA: IHME, University of Washington, Available from http://vizhub.healthdata.org/gbd-compare.

According to the Global Health Data Exchange, the YLL of Alzheimer’s disease and other dementias in Indonesia in 2017 is 522,067.55 (Global Health Data Exchange, 2019).

References:

Global Health Data Exchange. (2019). GBD Results Tool. http://ghdx.healthdata.org/gbd-results-tool

A total of 3205 deaths were attributed to dementia in 2016 showing an increase of 15.3% (95% UI 2.0 to 43.5) in age-standardised rates from 1990 to 2016 (Nichols et al., 2019). However, there is no information on YLL due to dementia specifically for Kenya.

References:

Nichols, E., Szoeke, C. E. I., Vollset, S. E., Abbasi, N., Abd-Allah, F., Abdela, J., … Murray, C. J. L. (2019). Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 18(1), 88–106. http://doi.org/10.1016/S1474-4422(18)30403-4

This information is not available.

Table 39 outlines the years of lives lost (YLL) due to dementia from the 2019 Global burden of disease report (Institute for Health Metrics and Evaluation, n.d.). Alzheimer’s and other dementias ranked as the 7th highest cause of YLL, up from 12th 20 years earlier, at 20,000 years.

Table 39: Deaths, Years lived with disability (YLD), and Disability Adjusted Life Years (DALYs) caused by dementia in 2017 (Institute for Health Metrics and Evaluation, n.d.)

Deaths YLD YLL DALY
Number 2,066 8,805 20,000 28,806
Rate (per 105) 46 196 445 641
Rank 2019 2 21 7 11
Rank 2000 6 26 12 20

 

References:

Institute for Health Metrics and Evaluation. (n.d.). Global Burden of Disease (GBD). IHME website. Available from: http://www.healthdata.org/gbd.

According to the Global Burden Disease Study (2017), the South Africa’s years of life lost due to Alzheimer’s disease and related dementias for 2016 were estimated at 86571,76 person-years (0.41%) (Global Burden Disease Study, 2017c).

References:

Global Burden Disease Study. (2017c). Global Burden Disease study: Results Tool (YLLs).